![]() However, very little is known about the structure-function relationship of the NTD, especially as an intrinsically disordered fragment of NRs that may influence the molecular properties and, in turn, the function of globular domains. There are numerous papers describing the molecular details of the latter two globular domains. NRs share a common structure comprising three domains: a variable N-terminal domain (NTD), a highly conserved globular DNA-binding domain and a ligand-binding domain. ![]() Nuclear receptors (NRs) are a family of ligand-dependent transcription factors activated by lipophilic compounds.
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